Not a local, but I'm an alternate-route fanatic, and I've scoped out most of the alternate routes in the resort districts of Orlando. The problem in getting from that area to USIOA bypassing I-4 is that the chain of lakes anchored by Lake Butler is in the way, and you have to either weave between them on winding residential streets, or go around them.
Assuming that she uses a toll transponder, the simplest alternate route is to go north on 429 to the Turnpike, then SE on the Turnpike to Universal. Mapping your way through the lakes is a PITA because so many of the subdivisions are gated, so although this route is much longer, I'd say it's the best alternate for when a Waze or Google Maps has identified a jam on I-4. (Although navigating that exit junction from the Turnpike to I-4W to Kirkman is kind of a wild mouse experience; one of the worst designs I've ever seen.)
If the jam is further north on I-4, the other option is to take I-4E as far as Apopka-Vineland, the take that north to Wallace Road and turn east. Wallace dead-ends into Turkey Lake Rd. right at the entrance to Volcano Bay.