I don't know if all of these will apply to your situation, but this is what I find helpful:
1. Unpack...assign each person a drawer...request extra hangers from housekeeping and hang up clothes that won't fit in drawers. Stow smaller luggage pieces inside bigger pieces if possible.
2. Toiletries...buy some relatively shallow, small plastic bins that can be stacked inside your suitcase and filed in with socks for travel (so they don't waste space), then unstack and assign each person one for their toiletries. Line bins up on shelf over closet bar. You could also use this idea for stuff like pens and autograph books.
3. Designate "zones"...mugs, food items, etc. go on the small table in the room; pens, autograph books, etc. go on top of the dresser/armoire; dirty clothes go in one spot only (laundry hamper is a great idea); spare change, wallets, valuable stuff goes in beside table drawer (only while you are in the room). This way everything has a home.
Hope this helps!