You're pretty much well set at those two properties, Lenny. Short of staying at a Disney resort, both hotels are ideally equipped to get the off-site non-driver around. The Mariott also gives you the option of walking to Downtown Disney or the Crossroads plaza, while the Wyndham is ideally siutated on I-Drive and is a very nice hotel (extensively refurbished last year).
Also, if you're going with Virgin, they have a new excursion available to the Kennedy Space Center, which I strongly recommend visiting if you can.