I've lived in the Cincinnati area all my life, so I know a little bit about the area.
The game is late afternoon (4:10 start), so I don't see them getting on the road before 7 or 7:30. That would put them in Knoxville sometime around 11:30. And that's actually going through the mountains very late at night (10:30-11)
Knoxville is about 4 hours from Cincinnati. We make the trip south all the time.
If you want to stop a little bit before Knoxville, Jellico has most of the major hotel chains. That's about 45 minutes north of Knoxville, just before the mountains.
Driving straight through with no stops, it's about 13 hours from here to Orlando. But we make a number of stops. Last trip took us about 15 to 15 1/2 hours.
Knoxville to Orlando is a relatively easy drive. Leave at 7 AM, you'll get through Atlanta well before noon.
Have fun at the game, and may the home team win.