Shamrocks, what time of day are you arriving? And are there kids with you?
"Why do you ask?", she wonders. Well, normally I agree with the usual wisdom that the 417/Greeneway is the best route.
However, if you're arriving early in the morning or later at night, then traffic on the 528/I-4 will not likely be a problem. In that case, I would (and do) take the *north* exit out of the airport, take the Beeline/528 west, pick up I-4, and head towards exit 26 to WDW.
Why this route? Yes, it's a tiny bit longer. Still has two toll booths. But it's filled with billboards advertising WDW (and Universal as well). As you drive, you get a preview of what's awaiting you. It's fun. It helps the anticipation. If you'll have kids in the car, you'll have fun with the "ooh, look at that!" reactions.
The Greeneway is a nice, useful, pleasant drive, and it has the advantage of a very useful and convenient grocery stop. But I enjoy the fun of driving down the Beeline - *IF* it's during a lighter traffic time.