We have done it several ways, and this way works best for us:
get on the FL turnpike at Wildwood (about exit 328) and take it to the US 27 exit and take 27 to 192. The construction is all finished on 192 and it goes very smoothly. We stop at the new Publix on 27 by the new Kings Ridge development, and it is an easy in/out with a light (we are driving a 31 foot RV so this is important!)
We've also tried going on the turnpike down to I4, but this is faster and more scenic.
Have fun planning!