I bought some packing cubes from ebags.com to use this trip and I am really enjoying them. I also bought some of the 2.5 gallon zipper bags at Target. I am packing everyone's socks and underthings in these.
I agree with another poster--make sure all toiletries are in zipper bags.
I have a toiletry bag that zips open and hangs from a hook once you are in the hotel room--This works great for me.
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I use the Eagle Creek packing system (cubes and a folder) and the same type toiletry bag you have. I also take a space bag to pack the dirty clothes I have to bring home.
The only thing I carry on is my prescription meds (in my purse), my trip binder and something to read.
Of course, I only have to pack for me. It makes things much easier