50 miles is not a long trip for Uber/Lyft; it's a nice trip...unless you are just about ready to quit for the evening. Also, at least with Uber, there is a "Long Ride" notification that is part of the ride request. It doesn't tell the driver your destination, or even direction, but it will tell them "Long Ride, 45+ minutes." So they will know, and they may call you and ask where or which direction you're headed.
Lyft also supposedly does the same thing, although I've personally never had one of their long ride notifications. Long rides, yes; notifications, no.
10 PM is also not late at night, especially on a Saturday. You might be taking that driver right where they want to be at 11 PM.
I know there are posters who have used Uber/Lyft from Sanford. Hopefully one of them, or one of the Orlando area drivers, can respond.
The other thing you can do is this Saturday about 10 PM, open up your Uber app, place your pin on the Sanford airport and see if you see any little ants crawling around. If you do, you won't have any trouble getting a ride. Just be sure your app is set on the correct type of ride (X, XL, etc) because it will only show cars in that class of service.